This short course will provide an introduction to mass spectrometry and the range of potential applications within drug discovery. We will cover the basic principles of mass spectrometry including the differences between the array of ionization modalities and detectors available today. While mass spectrometry has contributed significantly to drug discovery, recent advances are enabling high throughput screening applications.
Those interested in the following tracks:
Nearly 20 years experience of assay development and automation of high throughput screening for drug discovery within pharma. Joined AstraZeneca (AZ) in 2000 to deliver technology solutions to support pre-clinical screening within the Oncology disease area. Established a centralized biochemical screening group which received the 2008 Microsoft Innovation in Pharma Award. Involved in the deployment of acoustic technology within AZ which ultimately lead to a project to investigate the integration of an acoustic source as a loading system for mass spectrometry. This project received the Innovation Award at SLAS 2015.
With over 20 years of experience in mass spectrometry, gained initially with a major manufacturer building and supporting field instrumentation. Joined Astrazeneca in 2000 to support their suite of instruments and develop high throughput, open access solutions for chemistry and DMPK. More recently i have been invloved in applying these principles to generating detection systems for cellular and biochemical screening application and it is this work that has led to the development of the acoustic interface for a mass spectrometer.